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The maximum tolerated dose and recommended phase 2 dose of weekly administration of CRLX101 was determined to be 15 mg/m 2 , and 6/31 (19%) of patients achieved overall pathologic CR, with an additional 18/31 (58%) patients experienced a moderate response

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A literature and patent review published in Pharmaceuticals (MDPI) summarizes that BPC-157 demonstrates a desirable safety profile in preclinical research, with only a few side effects reported across animal studies, and documents its broad activity across tissue injury, inflammatory and CNS-adjacent research models via VEGFR2-Akt-eNOS angiogenic pathways and nitric oxide signaling